On December 23, Assistant Secretary of State for European and Eurasian Affairs A. Elizabeth Jones met with Ambassadors from Azerbaijan, Georgia, Moldova, Ukraine, and Uzbekistan to discuss future cooperation between the United States and GUUAM. At the meeting, both sides agreed to the next steps for a joint U.S.-GUUAM project on trade and transportation facilitation and law enforcement.

A new round of high-level GUUAM-U.S. consultations was held during the GUUAM Summit, July 3-4 in Yalta, Ukraine. Ambassador Steve Pifer, Deputy Assistant Secretary of State, led the U.S. delegation.
The Participants discussed the current state and prospects of the GUUAM-U.S. dialogue.

On September 23, 2004, in New York City, the GUUAM Countries and the United States met to further their dialogue and level of cooperation at the Seventh Meeting of the Council of Ministers for Foreign Affairs of GUUAM Countries. The U.S. delegation was led by Assistant Secretary of State for European and Eurasian Affairs A. Elizabeth Jones.

On September 16, 2005, the sixth consecutive Ministerial meeting of GUAM-USA was held in New York on the margins of the United Nations General Assembly.
The GUAM Foreign Ministers and U.S. Assistant Secretary of State Dan Fried discussed a wide range of issues, including GUAM-USA cooperation and progress in the implementation of the GUAM-USA Framework Program.

On October 30, 2007 a meeting of GUAM National Coordinators and the GUAM Secretary-General was held with senior officials of the U.S. Department of State and the U.S. Department of Justice in Washington, D.C.

During the meeting the participants discussed several issues related to cooperation between the United States and GUAM and identified new potential areas of common interest.

On December 4, 2008 in Helsinki, the 15th meeting of the GUAM Council of the Ministers for Foreign Affairs – United States of America was held within the framework of the 16th OSCE Ministerial Council Meeting.