On September 26, a new round of U.S.-GUUAM dialogue at the Ministerial level was held during the General Debates of the 58 Session of the United Nations General Assembly.
High representatives of the GUUAM member states and the U.S. discussed U.S.-GUUAM cooperation and progress on the U.S.-GUUAM Framework Program.

On April 21 and 22, 2005 in Chisinau, Moldova, the GUUAM Participating States and the United States met to advance their dialogue and cooperation at the Ninth Meeting of the Council of Ministers for Foreign Affairs of GUUAM Countries, on April 21, and the GUUAM Summit of Heads of State, on April 22. Ambassador Steven Mann, Senior Advisor for Eurasia, led the U.S. delegation.

On July 1, 2008 in Batumi, Georgia, a regular GUAM-USA meeting was held within the framework of the third Summit of the Organization for Democracy and Economic Development – GUAM. 
The sides highly assessed the level and scope of cooperation achieved and agreed to deepen and expand it further.

Азербайджанская Республика, Грузия, Республика Молдова, Республика Узбекистан и Украина, именуемые далее ГУУАМ,

руководствуясь положениями Устава Организации Объединенных Наций, а также Хельсинского Заключительного Акта, Парижской Хартии для новой Европы и Хартии европейской безопасно